Alagille Syndrome

Important
It is possible that the main title of the report Alagille Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

AHD
Arteriohepatic Dysplasia
Cholestasis with Peripheral Pulmonary Stenosis
Syndromatic Hepatic Ductular Hypoplasia

Disorder Subdivisions

None

General Discussion

Alagille syndrome is a genetic liver disorder usually present at birth. It is characterized by insufficient passage of bile due to a lower than normal number of bile ducts inside the liver. In some cases, the child may be born with no bile ducts. Major symptoms include prolonged yellow skin discoloration (jaundice), eye and heart structure anomalies, abnormally shaped vertebrae of the spine, compression of nerve space inside the lower spine, an absence of deep tendon reflexes, mental deficiency, facial and kidney (renal) abnormalities, shortened fingers, and pancreatic insufficiency.
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Resources

The Arc (a national organization on mental retardation)
1010 Wayne Ave
Suite 650
Silver Spring, MD 20910
Tel: (301)565-3842
Fax: (301)565-3843
Tel: (800)433-5255
TDD: (817)277-0553
Email: info@thearc.org
Internet: http://www.thearc.org/

Alagille Syndrome Alliance
10500 SW Starr Drive
Tualatin, OR 97062
USA
Tel: 5038850455
Fax: 5038850455
Email: alagille@earthlink.net
Internet: http://www.alagille.org

Children's Liver Alliance
IN
Email: mail@liverkids.org.au
Internet: http://www.liverkids.org.au

American Liver Foundation
75 Maiden Lane
Suite 603
New York, NY 10038
USA
Tel: 2126681000
Fax: 2124838179
Tel: 8004654837
Email: info@liverfoundation.org
Internet: http://www.liverfoundation.org

Digestive Disease National Coalition
507 Capitol Court
Suite 200
Washington, DC 20002
Tel: (202)544-7497
Fax: (202)546-7105
Email: scott@hmcw.org
Internet: http://www.ddnc.org

NIH/National Digestive Diseases Information Clearinghouse
2 Information Way
Bethesda, MD 20892-3570
Tel: (301)654-3810
Fax: (301)907-8906
Tel: (800)891-5389
Email: nddic@info.niddk.nih.gov
Internet: http://www.niddk.nih.gov

Cholestatic Liver Disease Consortium (CLiC)
c/o Joan Hines, The Children's Hospital
13123 E. 16th Ave.
Suite B290
Aurora, CO 80045
Tel: (720)777-2598
Fax: (720)777-7325
Email: hines.joan@tchden.org
Internet: http://www.rarediseasesnetwork.org/clic

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report.
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org
Last Updated: 8/8/2007
Copyright 1987, 1990, 1996, 1998, 1999, 2007 National Organization for Rare Disorders, Inc.

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